Cover art submissions to accompany the research article "Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome" by Waugh, et al, which ties the clinical phenotype of Down Syndrome to overexpression of the Interferon-a receptor. The genes for the two subunits of the receptor are located on chromosome 21. For more information see https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31352-X